Levels of biogenic amines in lung tissues of patients with non-small cell lung cancer after COVID-19 of various severity

Purpose of the study. Was to analyze levels biogenic amines (serotonin and its metabolite 5-HIAA, dopamine, norepinephrine histamine) in lung tissues patients with cancer previous COVID-19 infection. Patients methods. The study was carried out on samples intact tissues, tumor peritumoral obtained during open biopsy while performing radical surgery from morphologically verified non-small cell (NSCLC), stage I–IIIA (cT 1–3 N Х M 0 ). main group included 30 NSCLC (15 men 15 women) after severe or moderate who required hospitalization. control women asymptomatic mild SARS-CoV-2 mean age 59.11 ± 2.9 years. Levels norepinephrine, serotonin, 5-hydroxyindoleacetic acid (5-HIAA) histamine were measured by ELISA (IBL, Germany). Results. All studied tissue group, compared showed deficiency catecholamines their ratio unchanged, changes serotonin metabolism ensure stable level. Thus, dopamine lower average 1.3 times, 1.3–3.3 1.6 5-HIAA 1.8–4 times. At same time, sex differences observed levels. Regardless severity, diamine resection line an 2.4 men, but there no tissue. Conclusion. Apparently, could be associated severity Since is involved counteracting carcinogenic action adrenergic system regulation various immunocompetent cells microenvironment, such status lungs lead a more course.